个人介绍

     于圆圆，特聘教授，2017年博士毕业于清华大学，随后于芝加哥大学开展博士后研究，2021年加入集团。研究方向包括：一、拟基于开发抗体工具，实现不同翻译后修饰（尤其是泛素化修饰）在重要信号通路及疾病发生、发展中的功能解析。具体包括：1）翻译后修饰构象识别抗体工具的开发及功能解码；2） 绘制泛素密码在组织特异性和疾病特异性的“指纹图谱”，用于开发选择性调控或监测分子试剂。二、泛素相关蛋白质机器的酶学机制和化学调控研究。

       代表性成果以第一作者、共同第一作者或通讯作者发表于Nature，Nat. Chem. Biol.，Nat. Struct. Mol. Biol., Nat.Commun.，Angew. Chem. Int. Ed. 等化学、化员工物学领域顶级杂志。

主要研究领域

化员工物学，生物医药

代表性学术成果

1. Yu, Y.; Zheng, Q.; Pan, M.; et.al. Liu, L.*; Zhao, M.* K29-Linked Ubiquitin Signaling Regulates Proteotoxic Stress Response and Cell Cycle. Nat. Chem. Biol. 2021,17, 896.

2. Yu, Y.; Li, J. ^#; Jiang, L.; Zhang, J.*; Zu, L.* Catalytic Enantioselective Aza-pinacol Rearrangement. Angew. Chem. Int. Ed. 2017, 129, 9345.

3. Yu, Y.; Li, G. ^#; Jiang, L.; Zu, L.* An Indoxyl-Based Strategy for the Synthesis of Indolines and Indolenines. Angew. Chem. Int. Ed. 2015, 54, 12627.

4. Yu, Y.; Wang, C.; He, X.; Yao, X.; Zu, L.* Efficient Assembly of Polysubstituted Pyrroles via a (3+2) Cycloaddition/Skeletal Rearrangement/Redox Isomerization Cascade Reaction. Org. Lett. 2014, 16, 3580.

5.Yu, Y.; Li, G.; Zu, L.* The Development of Aza-Pinacol and Aza-Semipinacol Rearrangements for the Synthesis of Nitrogen-Containing Molecules. Synlett. 2016, 27, 1303. (invited Synpacts)

6.Pan, M. ^#; Yu, Y. ^#; Ai, H.; Zheng, Q.; Xie, Y.; Liu L. *; & Zhao, M.* Mechanistic insight into substrate processing and allosteric inhibition of human p97. Nat. Struct. Mol. Biol., 28, 614.

7. Pan, M. ^#; Zheng, Q. ^#; Yu, Y. ^#; et. al. Liu, L. *; Zhao, M. * Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative. Nat.Commun. 2021, doi: 10.1038/s41467-020-20359-x

8. Pan, M; Zheng, Q.; Wang, T.; Liang, L.; Mao, J.; Zuo, C.; Ding, R.; Ai, H.; Xie, Y.; Si, D.; Yu, Y. *; Liu, L.; * Zhao, M. *Structural Insights Into the Initiation and Elongation of Ubiquitination by Ubr1. Nature, 2021.